SALVAGE THERAPY WITH HIGH INTENSITY FOCUSED ULTRASOUND IN LOCAL RADIO RECURRENT PROSTATE CANCER

Introduction & Objectives.- To evaluate the predictive factors for local failure with follow-up- biopsy after whole-gland salvage HIFU in local radio-recurrent PCa pts and to analyses the effects adverse following the therapy in terms of morbidity and quality of life on short-term. Materials and Methods.-From April 2006 to Sept 2010. Fifty-five pts with biopsy-proven localized radio-recurrent PCa and no distant metastasis, were subjected to whole- gland salvage HIFU using Sonablate®500. PSA levels, IPSS, IIEF-5, QoL and Adverse events (CTCAE) questionnaires were assessed at 45, 90, 180 days and 12 months respectivelly. Follow-up biopsy was done systematically at 180 days after treatment. The data was prospectively collected and retrospectively analyzed. Potential predictive factors for local recurrence were explored using forward stepwise conditional regression. For comparison between groups, the Mann-Whitney U test, χ2, and Fisher’s exact test were used where appropriate. Two-sided p values