To prevent chromosome segregation errors, the spindle assembly checkpoint (SAC) delays mitosis exit until proper spindle assembly. We found that the FCP1 phosphatase and its downstream target WEE1 kinase oppose the SAC, promoting mitosis exit despite malformed spindles. We further showed that targeting this pathway might be useful for cancer therapy
Faithful chromosome segregation during mitosis depends on the spindle assembly checkpoint (SAC), whi...
Chromosomal instability (CIN) and aneuploidy are hallmarks of cancer. As most cancers are aneuploid,...
The research described in this thesis is focused on multiple pathways required for assembly of a bip...
To prevent chromosome segregation errors, the spindle assembly checkpoint (SAC) delays mitosis exit ...
The spindle assembly checkpoint (also known as the spindle or mitotic checkpoint) is a surveillance ...
Targeting the mitotic pathways of rapidly proliferating tumor cells has been an effective strategy i...
bly chromosomes are properly attached to the mitotic spindle. The SAC delays mitotic progression by ...
Mitosis represents a clinically important determination point in the life cycle of proliferating cel...
To grant faithful chromosome segregation, the spindle assembly checkpoint (SAC) delays mitosis exit ...
Even the most recent chemotherapeutic agents are either broad acting and carry with them a high degr...
The mitotic spindle assembly checkpoint (SCP) is a signal transduction pathway that ensures proper c...
BACKGROUND: The spindle assembly checkpoint is crucial for the maintenance of a stable chromosome nu...
SummaryCurrent antimitotics work by perturbing spindle assembly, which activates the spindle assembl...
Microtubule-targeting agents (MTAs) are used extensively for the treatment of diverse types of cance...
Cell division (mitosis) is a fundamental process in the life cycle of a cell. Equal distribution of ...
Faithful chromosome segregation during mitosis depends on the spindle assembly checkpoint (SAC), whi...
Chromosomal instability (CIN) and aneuploidy are hallmarks of cancer. As most cancers are aneuploid,...
The research described in this thesis is focused on multiple pathways required for assembly of a bip...
To prevent chromosome segregation errors, the spindle assembly checkpoint (SAC) delays mitosis exit ...
The spindle assembly checkpoint (also known as the spindle or mitotic checkpoint) is a surveillance ...
Targeting the mitotic pathways of rapidly proliferating tumor cells has been an effective strategy i...
bly chromosomes are properly attached to the mitotic spindle. The SAC delays mitotic progression by ...
Mitosis represents a clinically important determination point in the life cycle of proliferating cel...
To grant faithful chromosome segregation, the spindle assembly checkpoint (SAC) delays mitosis exit ...
Even the most recent chemotherapeutic agents are either broad acting and carry with them a high degr...
The mitotic spindle assembly checkpoint (SCP) is a signal transduction pathway that ensures proper c...
BACKGROUND: The spindle assembly checkpoint is crucial for the maintenance of a stable chromosome nu...
SummaryCurrent antimitotics work by perturbing spindle assembly, which activates the spindle assembl...
Microtubule-targeting agents (MTAs) are used extensively for the treatment of diverse types of cance...
Cell division (mitosis) is a fundamental process in the life cycle of a cell. Equal distribution of ...
Faithful chromosome segregation during mitosis depends on the spindle assembly checkpoint (SAC), whi...
Chromosomal instability (CIN) and aneuploidy are hallmarks of cancer. As most cancers are aneuploid,...
The research described in this thesis is focused on multiple pathways required for assembly of a bip...
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