Epilepsy and multiple sclerosis: Review of literature and our epilepsy center's experience

Aim of this paper is to examine the occurrence of epileptic seizures (ES) in our population of patients with definite Multiple sclerosis (MS) and to evaluate their clinical, EEG and MRI findings. Nine out our 250 (3.6%) MS patients experienced ES. In 3 cases, ES appeared within 1-2 yrs ("early-onset"), and in other 3 after 10 yrs ("late-onset") after MS diagnosis. In all pts but one, seizures were partial, usually with secondarily generalization. Prognosis of Epilepsy during MS seems to be quite favourable but the choice of the AED and whether to treat epileptic MS pts with IFNβ-1a or not, remain matter of debate