Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study
- Østergaard, Søren D
- Mukherjee, Shubhabrata
- Sharp, Stephen J
- Proitsi, Petroula
- Lotta, Luca A
- Day, Felix
- Perry, John R. B
- Boehme, Kevin L
- Walter, Stefan
- Kauwe, John S
- Gibbons, Laura E
- Larson, Eric B
- Powell, John F
- Langenberg, Claudia
- Crane, Paul K
- Wareham, Nicholas J
- Scott, Robert A.
- PANICO, SALVATORE
Publication date
January 2015
DOI Publisher
Public Library of Science (PLoS)Abstract
Potentially modifiable risk factors including obesity, diabetes, hypertension, and smoking are associated with Alzheimer disease (AD) and represent promising targets for intervention. However, the causality of these associations is unclear. We sought to assess the causal nature of these associations using Mendelian randomization (MR)
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