Impact of Environmental and Familial Factors in a Cohort of Pediatric Patients with Inflammatory Bowel Disease

OBJECTIVES: The primary role of environment on Inflammatory Bowel Disease (IBD) onset has been recently stressed. We aimed to investigate the impact of environmental factors in an IBD pediatric cohort. METHODS: A total of 467 subjects (264 IBD and 203 controls) were enrolled. All patients underwent a questionnaire including 5 different groups of environmental risk factors: family history of IBD and autoimmune diseases, perinatal period, home amenities and domestic hygiene, childhood diseases and vaccinations, diet. RESULTS: In a multivariate model, mother's degree (OR: 5.5; 2.5-11.6), duration of breast feeding >3 month (OR: 4.3; 1.6-10.5), father's employment (OR: 3.7; 1.2-8.7), gluten introduction <6 month (OR: 2.8; 1.5-5), number of siblings <2 (OR: 2.8; 1.5-5.3) and family history of autoimmune diseases (OR: 2.7; 1-4-5.3) were significant risk factors for CD. Low adherence to Mediterranean diet (OR: 2.3; 1.2-4.5), gluten introduction <6 month (OR: 2.8; 1.6-4.9) and number of siblings