pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom.
- Sutherland, Colin J
- Lansdell, Paul
- Sanders, Mandy
- Muwanguzi, Julian
- van Schalkwyk, Donelly A
- Kaur, Harparkash
- Nolder, Debbie
- Tucker, Julie
- Bennett, Hayley M
- Otto, Thomas D
- Berriman, Matthew
- Patel, Trupti A
- Lynn, Roderick
- Gkrania-Klotsas, Effrossyni
- Chiodini, Peter L
DOIAbstract
We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitemia within 6 weeks of treatment with no intervening travel to countries where malaria is endemic. Parasite isolates, all of African origin, harbored variants at some candidate resistance loci. No evidence of pfk13-mediated artemisinin resistance was found. Vigilance for signs of unsatisfactory antimalarial efficacy among imported cases of malaria is recommended
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