Exploring a new ultrasound score as a clinical predictive tool in patients with rheumatoid arthritis starting abatacept: results from the APPRAISE study

D'Agostino, M-A
Boers, M
Wakefield, RJ
Berner Hammer, H
Vittecoq, O
Filippou, G
Balint, P
Möller, I
Iagnocco, A
Naredo, E
Østergaard, M
Gaillez, C
Le Bars, M

Open PDF

Open link

Publication date

May 2016

DOI

10.1136/rmdopen-2015-000237

Publisher

BMJ

ISSN

2056-5933

Citation count (estimate)

Abstract

Objectives To explore whether changes in a composite (power Doppler/greyscale ultrasound (PDUS)) synovitis score, developed by the OMERACT-EULAR-Ultrasound Task Force, predict disease activity outcomes in rheumatoid arthritis (RA). Methods Patients with RA who were methotrexate inadequate responders starting abatacept were evaluated. Individual joint PDUS scores were combined in the Global OMERACT-EULAR Synovitis Score (GLOESS) for metacarpophalangeal joints (MCPs) 2–5, all joints (22 paired) and a reduced (9 paired) joint set. The predictive value of changes in GLOESS at week 1–16 evaluations for clinical status and response (Disease Activity Score (DAS)28 (C reactive protein, CRP) <2.6; DAS28(CRP) ≤3.2; DAS28(CRP) ≥1.2 improvement) up ...