Temporal bacterial and metabolic development of the preterm gut reveals specific signatures in health and disease
- Stewart, Christopher
- Embleton, Nicholas
- Marrs, Emma
- Smith, Daniel
- Nelson, Andrew
- Abdulkadir, Bashir
- Skeath, Tom
- Petrosino, Joseph
- Perry, John
- Berrington, Janet
- Cummings, Stephen
DOIAbstract
Background - The preterm microbiome is crucial to gut health and may contribute to necrotising enterocolitis (NEC), which represents the most significant pathology affecting preterm infants. From a cohort of 318 infants, <32 weeks gestation, we selected 7 infants who developed NEC (defined rigorously) and 28 matched controls. We performed detailed temporal bacterial (n = 641) and metabolomic (n = 75) profiling of the gut microbiome throughout the disease. Results - A core community of Klebsiella, Escherichia, Staphyloccocus, and Enterococcus was present in all samples. Gut microbiota profiles grouped into six distinct clusters, termed preterm gut community types (PGCTs). Each PGCT reflected dominance by the core operational taxonomic uni...
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