A novel erm(44) gene variant from a human Staphylococcus saprophyticus confers resistance to macrolides, lincosamides but not streptogramins.

A novel erm (44) gene variant, erm (44)v, has been identified by whole genome sequencing in a Staphylococcus saprophyticus isolated from the skin of a healthy person. It has the particularity to confer resistance to macrolides and lincosamides, but not to streptogramins B when expressed in S. aureus The erm (44)v gene resides on a 19,400-bp genomic island which contains phage-associated proteins and is integrated into the chromosome of S. saprophyticus