Physical activity attenuates the effect of the FTO genotype on obesity traits in European adults: the Food4Me study
- Celis-Morales, Carlos
- Marsaux, Cyril F.M.
- Livingstone, Katherine M.
- Navas-Carretero, Santiago
- San-Cristobal, Rodrigo
- O’Donovan, Clare B.
- Forster, Hannah
- Woolhead, Clara
- Fallaize, Rosalind
- Macready, Anna L.
- Kolossa, Silvia
- Hallmann, Jacqueline
- Tsirigoti, Lydia
- Lambrinou, Christina P.
- Moschonis, George
- Godlewska, Magdalena
- Surwiłło, Agnieszka
- Grimaldi, Keith
- Bouwman, Jildau
- Manios, Yannis
- Traczyk, Iwona
- Drevon, Christian A.
- Parnell, Laurence D.
- Daniel, Hannelore
- Gibney, Eileen R.
- Brennan, Lorraine
- Walsh, Marianne C.
- Gibney, Mike
- Lovegrove, Julie A.
- Martinez, J. Alfredo
- Saris, Wim H.M.
- Mathers, John C.
DOIAbstract
Objective: To examine whether the effect of FTO loci on obesity-related traits could be modified by physical activity (PA) levels in European adults. Methods: Of 1,607 Food4Me participants randomized, 1,280 were genotyped for FTO (rs9939609) and had available PA data. PA was measured objectively using accelerometers (TracmorD, Philips), whereas anthropometric measures [BMI and waist circumference (WC)] were self-reported via the Internet. Results: FTO genotype was associated with a higher body weight [b: 1.09 kg per risk allele, (95% CI:0.14-2.04), P=0.024], BMI [b: 0.54 kg m-2, (0.23-0.83), P<0.0001], and WC [b: 1.07 cm, (0.24-1.90),P=0.011]. Moderate-equivalent PA attenuated the effect of FTO on BMI (P[interaction]=0.020). Among inact...
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