M.Sc. (Chemistry)Inhibition of mycothiol biosynthesis pathway has attracted attention from chemists and biochemists who aim to develop novel anti-TB drugs. A possible route to inhibit the production of mycothiol in cells may be via the inhibition of enzymes involved in the biosynthetic pathways. Molecular analogues that mimic mycothiol and containing tetrahedral-forming functional groups have been reported to show activity against mycothiol biosynthesis by inhibiting the enzymes in the mycothiol biosynthetic pathway..
Since the discovery of a flavin-dependent thymidylate synthase (ThyX or FDTS) that is absent in huma...
Mycobacterium tuberculosis salicylate synthase (MbtI) catalyses the first committed step in the bios...
Tuberculosis (TB) causes millions of deaths every year, ranking as one of the most dangerous infecti...
M.Sc. (Chemistry)Inhibition of mycothiol biosynthesis pathway has attracted attention from chemists ...
Mycobacterium tuberculosis kills approximately two million people each year and is second only to HI...
TB is the second leading cause of morbidity world wide caused by a single infectious organism. One t...
Mycothiol is found only in Actinobacteria including M. tuberculosis, and appears to play an importan...
This thesis was concerned with the design and synthesis of compounds which are either substrate-mimi...
Mycobacterium tuberculosis salicylate synthase (MbtI), a member of the chorismate-utilizing enzyme f...
The work described in this dissertation covers a wide range of disciplines within organic chemistry,...
Abstract: Mycothiol (MSH), the major cellular thiol in Mycobacterium tuberculosis (Mtb), plays an es...
Mycothiol is found in Gram-positive bacteria, where it helps in maintaining a reducing intracellular...
Tuberculosis nowadays ranks as the second leading cause of death from an infectious disease worldwid...
The synthesis of candidate inhibitors of Mycobacterium tuberculosis cell-wall biosynthesis as potent...
Includes bibliographical referencesThe emergence of multiple drug resistant (MDR) and extremely drug...
Since the discovery of a flavin-dependent thymidylate synthase (ThyX or FDTS) that is absent in huma...
Mycobacterium tuberculosis salicylate synthase (MbtI) catalyses the first committed step in the bios...
Tuberculosis (TB) causes millions of deaths every year, ranking as one of the most dangerous infecti...
M.Sc. (Chemistry)Inhibition of mycothiol biosynthesis pathway has attracted attention from chemists ...
Mycobacterium tuberculosis kills approximately two million people each year and is second only to HI...
TB is the second leading cause of morbidity world wide caused by a single infectious organism. One t...
Mycothiol is found only in Actinobacteria including M. tuberculosis, and appears to play an importan...
This thesis was concerned with the design and synthesis of compounds which are either substrate-mimi...
Mycobacterium tuberculosis salicylate synthase (MbtI), a member of the chorismate-utilizing enzyme f...
The work described in this dissertation covers a wide range of disciplines within organic chemistry,...
Abstract: Mycothiol (MSH), the major cellular thiol in Mycobacterium tuberculosis (Mtb), plays an es...
Mycothiol is found in Gram-positive bacteria, where it helps in maintaining a reducing intracellular...
Tuberculosis nowadays ranks as the second leading cause of death from an infectious disease worldwid...
The synthesis of candidate inhibitors of Mycobacterium tuberculosis cell-wall biosynthesis as potent...
Includes bibliographical referencesThe emergence of multiple drug resistant (MDR) and extremely drug...
Since the discovery of a flavin-dependent thymidylate synthase (ThyX or FDTS) that is absent in huma...
Mycobacterium tuberculosis salicylate synthase (MbtI) catalyses the first committed step in the bios...
Tuberculosis (TB) causes millions of deaths every year, ranking as one of the most dangerous infecti...