Influence of a caffeine mouth rinse on sprint cycling following glycogen depletion

Attenuated performance during intense exercise with limited endogenous carbohydrate (CHO) is well documented. Therefore, this study examined whether caffeine (CAF) mouth rinsing would augment performance during repeated sprint cycling in participants with reduced endogenous CHO. Eight recreationally active males (aged 23 ± 2 yr, body mass 84 ± 4 kg, stature 178 ± 7 cm) participated in this randomized, single-blind, repeated-measures crossover investigation. Following familiarization, participants attended two separate evening glycogen depletion sessions. The following morning, participants completed five, 6 s sprints on a cycle ergometer (separated by 24 s active recovery), with mouth rinsing either 1) a placebo solution or 2) a 2% caffeine solution. During a fifth visit, participants completed the sprints without prior glycogen depletion. Repeated measures ANOVA identified significant main effect of condition (CAF, placebo, and control [P<0.05; ES=0.850-0.897]), sprint (1-5 [P<0.005; ES=0.871-0.986]), and interaction (condition x sprint [P<0.05; ES=0.831-0.846]), for peak and mean power. The control condition exhibited the highest peak power (overall mean 760 ± 77 W) and mean power (overall mean 699 ± 83W) over the five sprints (P<0.001 in both instances). CAF peak power (overall mean 643 ± 79 W) was significantly greater than placebo (mean 573 ± 79 W [P<0.05; ES=0.850]). Additionally, CAF mean power (overall mean 589 ± 80 W) was significantly greater than placebo (519 ± 82 W [P