Synthesis of brominated marine natural product amathamide F is described. Various strategies to construct the enamide functionality required for its synthesis have been explored. Finally, we succeeded in constructing the enamide moiety under a palladium-catalyzed condition. Facile transformation of 2,3,4-tribromo-5-methoxybenzaldehyde to the reported structure of amathamide F involved initial one-carbon-elongation of the aldehyde group followed by its conversion to corresponding enol acetate derivative prior to crucial Pd(II)-catalyzed cross-coupling with (S)-1-methylpyrrolidine-2-carboxamide. However, due to nonconformity of its NMR spectral data to that of the reported natural isolate, we have confirmed its actual structure through a synt...
How to cite Complete issue More information about this article Journal's homepage in redalyc.or...
Palladium-catalyzed carboamination (simultaneous formation of C-N and C-C bonds from an olefin) has ...
A synthetic route to alkaloid natural products is demonstrated via palladium-catalyzed cross-couplin...
Marine natural products have long served as promising compounds and scaffolds for new therapeutic ag...
Total synthesis of the published structure of amathamide D is described. Methyl 2,3,4-tribromo-5-hyd...
Total synthesis of the published structure of amathamide D is described. Methyl 2,3,4-tribromo-5-hyd...
Catalysts generated from Pd2(dba)3 and biphenyl ligands 4 and 7 efficiently promote the coupling of ...
This thesis comprises of two main parts:indium-mediated THP ring formation and functional group tran...
A Pd-catalyzed methodology for the preparation of tertiary enamides from acyclic secondary amides an...
A palladium-catalyzed synthesis of the carbazole framework is described, including the preparation o...
A palladium-catalyzed synthesis of the carbazole framework is described, including the preparation o...
Functionalization of enamides via allylic alkylation was achieved under the catalysis of palladiu...
Alkaloids are groups of naturally occurring compounds containing basic nitrogen atoms. They are prod...
This thesis describes studies towards the total synthesis of manzamine A (9), a marine alkaloid. Two...
The initial aim of this project was to investigate ways of synthesising fused, spirocyclic and linke...
How to cite Complete issue More information about this article Journal's homepage in redalyc.or...
Palladium-catalyzed carboamination (simultaneous formation of C-N and C-C bonds from an olefin) has ...
A synthetic route to alkaloid natural products is demonstrated via palladium-catalyzed cross-couplin...
Marine natural products have long served as promising compounds and scaffolds for new therapeutic ag...
Total synthesis of the published structure of amathamide D is described. Methyl 2,3,4-tribromo-5-hyd...
Total synthesis of the published structure of amathamide D is described. Methyl 2,3,4-tribromo-5-hyd...
Catalysts generated from Pd2(dba)3 and biphenyl ligands 4 and 7 efficiently promote the coupling of ...
This thesis comprises of two main parts:indium-mediated THP ring formation and functional group tran...
A Pd-catalyzed methodology for the preparation of tertiary enamides from acyclic secondary amides an...
A palladium-catalyzed synthesis of the carbazole framework is described, including the preparation o...
A palladium-catalyzed synthesis of the carbazole framework is described, including the preparation o...
Functionalization of enamides via allylic alkylation was achieved under the catalysis of palladiu...
Alkaloids are groups of naturally occurring compounds containing basic nitrogen atoms. They are prod...
This thesis describes studies towards the total synthesis of manzamine A (9), a marine alkaloid. Two...
The initial aim of this project was to investigate ways of synthesising fused, spirocyclic and linke...
How to cite Complete issue More information about this article Journal's homepage in redalyc.or...
Palladium-catalyzed carboamination (simultaneous formation of C-N and C-C bonds from an olefin) has ...
A synthetic route to alkaloid natural products is demonstrated via palladium-catalyzed cross-couplin...