The IκB kinase (IKKα, β and the regulatory subunit IKKγ) complex regulates nuclear factor of κB (NF-κB) transcriptional activity, which is upregulated in many chronic inflammatory diseases. NF-κB signaling promotes inflammation and limits muscle regeneration in Duchenne muscular dystrophy (DMD), resulting in fibrotic and fatty tissue replacement of muscle that exacerbates the wasting process in dystrophic muscles. Here, we examined whether dominant-negative forms of IKKα (IKKα-dn) and IKKβ (IKKβ-dn) delivered by adeno-associated viral (AAV) vectors to the gastrocnemius (GAS) and tibialis anterior (TA) muscles of 1, 2 and 11-month-old mdx mice, a murine DMD model, block NF-κB activation and increase muscle regeneration. At 1 month post-treat...
Dystrophin gene transfer using helper-dependent adenoviral vectors (HDAd) deleted of all viral genes...
The inhibitor of apoptosis (IAP) proteins traditionally regulate programmed cell death by binding to...
Duchenne muscular dystrophy (DMD) is a genetic disease characterized by muscle wasting and chronic i...
The IκB kinase (IKKα, β and the regulatory subunit IKKγ) complex regulates nuclear factor of κB (NF-...
Inhibition of the inhibitor of kappa B kinase (IKK)/nuclear factor-kappa B (NF-κB) pathway enhances ...
Chronic inflammation, promoted by an upregulated NF-kappa B (NF-κB) pathway, has a key role in Duche...
Duchenne muscular dystrophy (DMD) is a fatal disease characterized by progressive skeletal muscle de...
NF-κB is a major pleiotropic transcription factor modulating immune, inflammatory, cell survival, an...
AbstractMuscle wasting accompanies aging and pathological conditions ranging from cancer, cachexia, ...
International audienceAbstract Duchenne muscular dystrophy is a severe neuromuscular disease causing...
Duchenne muscular dystrophy (DMD) is one of the most common muscle disorders affecting about 1 in 35...
KEY POINTS: Adeno-associated viral vector was used to elevate the expression of muscle specific kina...
International audienceMuscle is an attractive target because it is easily accessible; it also offers...
Inflammation plays a considerable role in the progression of Duchenne Muscular Dystrophy (DMD), a se...
Dystrophin gene transfer using helper-dependent adenoviruses (HDAd), which are deleted of all viral ...
Dystrophin gene transfer using helper-dependent adenoviral vectors (HDAd) deleted of all viral genes...
The inhibitor of apoptosis (IAP) proteins traditionally regulate programmed cell death by binding to...
Duchenne muscular dystrophy (DMD) is a genetic disease characterized by muscle wasting and chronic i...
The IκB kinase (IKKα, β and the regulatory subunit IKKγ) complex regulates nuclear factor of κB (NF-...
Inhibition of the inhibitor of kappa B kinase (IKK)/nuclear factor-kappa B (NF-κB) pathway enhances ...
Chronic inflammation, promoted by an upregulated NF-kappa B (NF-κB) pathway, has a key role in Duche...
Duchenne muscular dystrophy (DMD) is a fatal disease characterized by progressive skeletal muscle de...
NF-κB is a major pleiotropic transcription factor modulating immune, inflammatory, cell survival, an...
AbstractMuscle wasting accompanies aging and pathological conditions ranging from cancer, cachexia, ...
International audienceAbstract Duchenne muscular dystrophy is a severe neuromuscular disease causing...
Duchenne muscular dystrophy (DMD) is one of the most common muscle disorders affecting about 1 in 35...
KEY POINTS: Adeno-associated viral vector was used to elevate the expression of muscle specific kina...
International audienceMuscle is an attractive target because it is easily accessible; it also offers...
Inflammation plays a considerable role in the progression of Duchenne Muscular Dystrophy (DMD), a se...
Dystrophin gene transfer using helper-dependent adenoviruses (HDAd), which are deleted of all viral ...
Dystrophin gene transfer using helper-dependent adenoviral vectors (HDAd) deleted of all viral genes...
The inhibitor of apoptosis (IAP) proteins traditionally regulate programmed cell death by binding to...
Duchenne muscular dystrophy (DMD) is a genetic disease characterized by muscle wasting and chronic i...