An emerging paradigm shift in bacterial pathogenesis has resulted in renewed interest in metabolism during infection. The acquisition and synthesis of metabolites by pathogens in the host represents a critical obstacle to successful colonization and infection. The value of bacterial metabolic pathways during infection remains poorly characterized for many pathogens and warrants further investigation. One aspect of this, the contribution of one-carbon metabolism to pathogenic fitness was assessed. This metabolic pathway primarily transfers single carbons and contributes to the synthesis of amino acids, DNA, and proteins. The donated carbon is typically derived from 5,10-methylenetetrahydrofolate, a central compound in one-carbon metabo...
Listeria monocytogenes is a foodborne human pathogen that can cause invasive infection in susceptibl...
Analysis of the genome sequences of the major human bacterial pathogens has provided a large amount ...
The study of metabolic changes associated with host-pathogen interactions have largely focused on th...
An emerging paradigm shift in bacterial pathogenesis has resulted in renewed interest in metabolism ...
Intracellular multiplication and dissemination of the infectious bacterial pathogen Francisella tula...
Francisella tularensis is a small Gram negative coccobacillus that is the causative agent of the dis...
Once relegated to the supply of energy and biosynthetic precursors, it is now indubitable that metab...
Thesis (Ph.D.)--University of Washington, 2020The survival of pathogenic intracellular bacteria reli...
International audienceFrancisella tularensis is the causative agent of tularemia. Because of its ext...
During conditions of nutrient limitation bacteria undergo a series of global gene expression changes...
The bacterial pathogen Salmonella enterica is responsible for considerable global morbidity and mort...
This dissertation presents investigations into the carbon source utilization pathways and stress con...
Francisella tularensis is a highly virulent intracellular pathogen that invades and replicates withi...
Analysis of the genome sequences of the major human bacterial pathogens has provided a large amount ...
Francisella tularensis is an intracellular pathogen for many animals causing the infectious disease,...
Listeria monocytogenes is a foodborne human pathogen that can cause invasive infection in susceptibl...
Analysis of the genome sequences of the major human bacterial pathogens has provided a large amount ...
The study of metabolic changes associated with host-pathogen interactions have largely focused on th...
An emerging paradigm shift in bacterial pathogenesis has resulted in renewed interest in metabolism ...
Intracellular multiplication and dissemination of the infectious bacterial pathogen Francisella tula...
Francisella tularensis is a small Gram negative coccobacillus that is the causative agent of the dis...
Once relegated to the supply of energy and biosynthetic precursors, it is now indubitable that metab...
Thesis (Ph.D.)--University of Washington, 2020The survival of pathogenic intracellular bacteria reli...
International audienceFrancisella tularensis is the causative agent of tularemia. Because of its ext...
During conditions of nutrient limitation bacteria undergo a series of global gene expression changes...
The bacterial pathogen Salmonella enterica is responsible for considerable global morbidity and mort...
This dissertation presents investigations into the carbon source utilization pathways and stress con...
Francisella tularensis is a highly virulent intracellular pathogen that invades and replicates withi...
Analysis of the genome sequences of the major human bacterial pathogens has provided a large amount ...
Francisella tularensis is an intracellular pathogen for many animals causing the infectious disease,...
Listeria monocytogenes is a foodborne human pathogen that can cause invasive infection in susceptibl...
Analysis of the genome sequences of the major human bacterial pathogens has provided a large amount ...
The study of metabolic changes associated with host-pathogen interactions have largely focused on th...