Defining context specific requirements for proteins and pathways is a major challenge in the study of signal transduction. For example, the stress-activated protein kinase (SAPK) pathways are comprised of families of closely related transducers that are activated in a variety of tissues and contexts during development and organismal homeostasis. Consequently, redundant and pleiotropic effects have hampered a complete understanding of the individual contributions of transducers in distinct contexts. Here, we report on the function of a context-specific regulatory phosphorylation site, PXSP, in the Drosophila mixed lineage kinase protein, Slpr, a mitogen-activated protein kinase kinase kinase (MAP3K) in the Jun Kinase (JNK) pathway. Genetic a...
Human diseases such as spina bifida are caused by a failure in cell morphogenesis and tissue fusion....
Heat shock response is a homeostatic adaptive response exhibited by nearly all cells in response to ...
The heat shock response (HSR) is a highly conserved mechanism that enables organisms to survive envi...
Defining context specific requirements for proteins and pathways is a major challenge in the study o...
Defining context specific requirements for proteins and pathways is a major challenge in the study o...
<div><p>Defining context specific requirements for proteins and pathways is a major challenge in the...
Defining context specific requirements for proteins and pathways is a major challenge in the study o...
Signal transduction pathways rely on proper protein activation and regulation to elicit appropriate ...
Cells commonly use multiprotein kinase cascades to signal information from the cell membrane to the ...
The p38 mitogen-activated protein kinase (MAPK) signaling pathway plays an important role in cellula...
Mammalian c-Jun N-terminal kinases (JNKs) are members of a group of stress-activated intracellular s...
Mammalian c-Jun N-terminal kinases (JNKs) are members of a group of stress-activated intracellular s...
AbstractMixed lineage kinases (MLKs) belong to the family of mitogen activated protein kinase kinase...
Cellular signaling networks have evolved to enable swift and accurate responses, even in the face of...
In eukaryotes, histone H3 residues at the promoter and transcriptional start site of immediate early...
Human diseases such as spina bifida are caused by a failure in cell morphogenesis and tissue fusion....
Heat shock response is a homeostatic adaptive response exhibited by nearly all cells in response to ...
The heat shock response (HSR) is a highly conserved mechanism that enables organisms to survive envi...
Defining context specific requirements for proteins and pathways is a major challenge in the study o...
Defining context specific requirements for proteins and pathways is a major challenge in the study o...
<div><p>Defining context specific requirements for proteins and pathways is a major challenge in the...
Defining context specific requirements for proteins and pathways is a major challenge in the study o...
Signal transduction pathways rely on proper protein activation and regulation to elicit appropriate ...
Cells commonly use multiprotein kinase cascades to signal information from the cell membrane to the ...
The p38 mitogen-activated protein kinase (MAPK) signaling pathway plays an important role in cellula...
Mammalian c-Jun N-terminal kinases (JNKs) are members of a group of stress-activated intracellular s...
Mammalian c-Jun N-terminal kinases (JNKs) are members of a group of stress-activated intracellular s...
AbstractMixed lineage kinases (MLKs) belong to the family of mitogen activated protein kinase kinase...
Cellular signaling networks have evolved to enable swift and accurate responses, even in the face of...
In eukaryotes, histone H3 residues at the promoter and transcriptional start site of immediate early...
Human diseases such as spina bifida are caused by a failure in cell morphogenesis and tissue fusion....
Heat shock response is a homeostatic adaptive response exhibited by nearly all cells in response to ...
The heat shock response (HSR) is a highly conserved mechanism that enables organisms to survive envi...