Orientation of organelles inside T cells (TC) toward antigen-presenting cells (APC) ensures that the immune response is properly directed, but the orientation mechanisms remain largely unknown. Structural dynamics of TC are coupled to dynamics of T-cell receptor (TCR), which recognizes antigen on the APC surface. Engagement of the TCR triggers its internalization followed by delayed polarized recycling to the plasma membrane through the submembrane recycling compartment (RC), which organelle shares intracellular location with the TC effector apparatus. TCR engagement also triggers TC-APC interface expansion enabling further receptor engagement. To analyze the interplay of the cell-cell contact and receptor dynamics, we constructed a new num...
Endocytosis of surface receptors and their polarized recycling back to the plasma membrane are centr...
Understanding the component stoichiometry of the T cell antigen receptor (TCR) triggering apparatus ...
Ligand binding to the T-cell antigen receptor (TCR) evokes receptor triggering and subsequent T-lymp...
Orientation of organelles inside T cells (TC) toward antigen-presenting cells (APC) ensures that the...
AbstractActivation of T cells of the immune system involves recognition of the antigen by the T cell...
The mechanism by which T cell antigen receptors (TCR) accumulate at the immunological synapse has no...
T lymphocyte activation by specific antigen requires prolonged TCR occupancy and sustained signaling...
T cells are critically important for host defense against infections. T cell activation is specific ...
The adaptive immune responses are initiated by interaction of T cells and antigen- presenting cells ...
AbstractRecognition of peptide antigen by T cells involves coordinated movement of T cell receptors ...
Despite intensive investigation, the mechanisms of T cell receptor (TCR)-mediated signal generation ...
Understanding the component stoichiometry of the T cell antigen receptor (TCR) triggering apparatus ...
A critical step in mounting an immune response is antigen recognition by T cells. This step proceed...
T cell triggering through T-cell antigen receptors (TCRs) results in spatial assembly of the recepto...
As immune cells patrol our body, contacting and surveying the cells around them, they must constantl...
Endocytosis of surface receptors and their polarized recycling back to the plasma membrane are centr...
Understanding the component stoichiometry of the T cell antigen receptor (TCR) triggering apparatus ...
Ligand binding to the T-cell antigen receptor (TCR) evokes receptor triggering and subsequent T-lymp...
Orientation of organelles inside T cells (TC) toward antigen-presenting cells (APC) ensures that the...
AbstractActivation of T cells of the immune system involves recognition of the antigen by the T cell...
The mechanism by which T cell antigen receptors (TCR) accumulate at the immunological synapse has no...
T lymphocyte activation by specific antigen requires prolonged TCR occupancy and sustained signaling...
T cells are critically important for host defense against infections. T cell activation is specific ...
The adaptive immune responses are initiated by interaction of T cells and antigen- presenting cells ...
AbstractRecognition of peptide antigen by T cells involves coordinated movement of T cell receptors ...
Despite intensive investigation, the mechanisms of T cell receptor (TCR)-mediated signal generation ...
Understanding the component stoichiometry of the T cell antigen receptor (TCR) triggering apparatus ...
A critical step in mounting an immune response is antigen recognition by T cells. This step proceed...
T cell triggering through T-cell antigen receptors (TCRs) results in spatial assembly of the recepto...
As immune cells patrol our body, contacting and surveying the cells around them, they must constantl...
Endocytosis of surface receptors and their polarized recycling back to the plasma membrane are centr...
Understanding the component stoichiometry of the T cell antigen receptor (TCR) triggering apparatus ...
Ligand binding to the T-cell antigen receptor (TCR) evokes receptor triggering and subsequent T-lymp...