Preparation of sugar beta-amino acid derivatives with cyclic structures via ring closing metathesis

International audienceEfficient syntheses of β-amino acid derivatives with cyclic structures were developed. The key steps involve aza-Michael addition and ruthenium-catalyzed allylation for the construction of new acyclic β-amino acid dienes incorporating a sugar fragment, and a ruthenium-catalyzed ring-closing metathesis for the construction of the seven- and nine-membered ring compounds