This research studies the contributions of the application of RFID technology in transport and to evaluate the impact of this integration on the performance of the Global Supply Chain. We put a special focus on the importance of providing continuous traceability in a complex environment where reactive decisions must be made following the occurrence of uncertain events. We analyse the suitability of implementing RFID technology in picking, loading, routing and unloading processes, while highlighting how the Supply Chain reacts to the different hazards that products can face during their transfer to customers. To measure the impact of the integration of RFID on the performance of the Supply Chain, we adopt a simulation-based approach to enabl...