Copper N-heterocyclic carbene complexes as active catalysts for the synthesis of 2-substituted oxazolines from nitriles and aminoalcohols

The authors gratefully acknowledge the Royal Society (University research Fellowship to C.S.J.C) for funding.The reaction between nitriles and aminoalcohols to access 2-substituted oxazolines was investigated. Using copper–NHC complexes, various nitriles were successfully converted into the corresponding oxazolines, under milder and less wasteful conditions than previously reported methods.PostprintPeer reviewe