Add to ORKGConiine is a toxic alkaloid that is isolated from spotted hemlock.The molecule has been a popular synthetic target for showcasing new methods of enantioselective synthesis. Our own strategy for the synthesis of coniine blends the enantioselectivity of an enzyme with the rich organometallic chemistry of p-allyl palladium substitutions and ruthenium-catalyzed ring-closing metathesis
A novel stereoselective synthesis of isofagomine using a readily available enzyme is described. Crot...
Ring closing metathesis employing the well-known Grubbs' ruthenium catalyst has been used as the key...
Synthesis of enantiomerically pure and biologically important molecules is one of the most challengi...
(-)-Coniine is a toxic six-membered ring alkaloid that is isolated from spotted hemlock. The molecul...
Enantioselective syntheses have become increasingly important since the FDA declared enantiomers as ...
We have developed a novel strategy for the enantiospecific synthesis of substituted piperidine struc...
γ-Coniceine, coniine, and N-methylconiine are toxic alkaloids present in poison hemlock (Conium macu...
The first total synthesis of (+)-conagenin, a novel immunomodulator produced by Streptomyces roseosp...
Stereochemistry and enantiopurity are important aspects of biologically active molecules. Our resear...
Coniine is a toxic alkaloid, the biosynthesis of which is not well understood. A possible route, sup...
The ability of the catalytic, asymmetric acyl halide-aldehyde cyclocondensation (AAC) reaction to pr...
Poison hemlock (Conium maculatum L.) is a poisonous plant which is speculated to have been the main ...
A flexible synthetic route to (R)-harmonine ((R)-1), the toxic principle of the Asian lady beetle Ha...
An ω‐transaminase triggered intramolecular aza‐Michael reaction has been employed for the preparatio...
Global sales of single enantiomeric drug products are growing at an alarming rate every year. A tota...
A novel stereoselective synthesis of isofagomine using a readily available enzyme is described. Crot...
Ring closing metathesis employing the well-known Grubbs' ruthenium catalyst has been used as the key...
Synthesis of enantiomerically pure and biologically important molecules is one of the most challengi...
(-)-Coniine is a toxic six-membered ring alkaloid that is isolated from spotted hemlock. The molecul...
Enantioselective syntheses have become increasingly important since the FDA declared enantiomers as ...
We have developed a novel strategy for the enantiospecific synthesis of substituted piperidine struc...
γ-Coniceine, coniine, and N-methylconiine are toxic alkaloids present in poison hemlock (Conium macu...
The first total synthesis of (+)-conagenin, a novel immunomodulator produced by Streptomyces roseosp...
Stereochemistry and enantiopurity are important aspects of biologically active molecules. Our resear...
Coniine is a toxic alkaloid, the biosynthesis of which is not well understood. A possible route, sup...
The ability of the catalytic, asymmetric acyl halide-aldehyde cyclocondensation (AAC) reaction to pr...
Poison hemlock (Conium maculatum L.) is a poisonous plant which is speculated to have been the main ...
A flexible synthetic route to (R)-harmonine ((R)-1), the toxic principle of the Asian lady beetle Ha...
An ω‐transaminase triggered intramolecular aza‐Michael reaction has been employed for the preparatio...
Global sales of single enantiomeric drug products are growing at an alarming rate every year. A tota...
A novel stereoselective synthesis of isofagomine using a readily available enzyme is described. Crot...
Ring closing metathesis employing the well-known Grubbs' ruthenium catalyst has been used as the key...
Synthesis of enantiomerically pure and biologically important molecules is one of the most challengi...