OGA Inhibition By GlcNAc-Selenazoline
- Kim, E. J.
- Love, D. C.
- Darout, E.
- Abdo, M.
- Rempel, B.
- Withers, S. G.
- Rablen, Paul R.
- Hanover, J. A.
- Knapp, S.
Publication date
October 2010
DOI Publisher
Transformative Works and Cultures ISSN
0968-0896 Citation count (estimate)
5Abstract
The title compound, which differs from the powerful O-GlcNAcase (OGA) inhibitor GlcNAc-thiazoline only at the chalcogen atom (Se for S), is a much weaker inhibitor in a direct OGA assay. In human cells, however, the selenazoline shows comparable ability to induce hyper-O-GlcNAc-ylation, and the two show similar reduction of insulin-stimulated translocation of glucose transporter 4 in differentiated 3T3 adipocytes. (C) 2010 Elsevier Ltd. All rights reserved
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