The remarkable selectivity of N-methyl mesoporphyrin IX (NMM) for G-quadruplexes (GQs) is long known, however its ability to stabilize and bind GQs has not been investigated in detail. Through the use of circular dichroism, UV-visible spectroscopy and fluorescence resonance energy transfer (FRET) melting assay we have shown that NMM stabilizes human telomeric DNA dAG(3)(TTAG(3))(3) (Tel22) and is selective for its parallel conformation to which it binds in 1:1 stoichiometry with a binding constant of similar to 1.0 x 10(5) M-1. NMM does not interact with an antiparallel conformation of Tel22 in sodium buffer and is the second example in the literature, after TOxaPy, of a ligand with an excellent selectivity for a specific GQ structure. NMM\...
The quadruplex forming G-rich sequences are unevenly distributed throughout the human genome. Their ...
Telomere shortening is primarily involved in cell death and cellular aging. However, telomerase can ...
G-quadruplex (GQ) DNA is a non-canonical DNA structure thought to form throughout the human genome. ...
The remarkable selectivity of N-methyl mesopor-phyrin IX (NMM) for G-quadruplexes (GQs) is long know...
N-Methyl mesoporphyrin IX (NMM) is exceptionally selective for G-quadruplexes (GQ) relative to duple...
<i>N-</i>Methyl mesoporphyrin IX (NMM) is exceptionally selective for G-quadruplexes (GQ) relative t...
The G-quadruplex (GQ) is a well-studied non-canonical DNA structure formed by G-rich sequences found...
G-quadruplexes (GQs) are noncauonical secondary structures of DNA that can adopt a multitude of diff...
The G-quadruplex (GQ) is a well-studied non-canonical DNA structure formed by G-rich sequences found...
N-methyl mesoporphyrin IX (NMM) is a water-soluble, non-symmetric porphyrin with excellent optical p...
G-quadruplexes (GQs) are non-canonical DNA structures composed of stacks of stabilized guanine tetra...
Non-canonical DNA structures known as G-quadruplexes (GQs) and i-motifs can form from G-rich and C-r...
G-rich DNA sequences have the potential to fold into non-canonical G-Quadruplex (GQ) structures impl...
G-rich DNA sequences have the potential to fold into non-canonical G-Quadruplex (GQ) structures impl...
AbstractStructural complexity is an inherent feature of the human telomeric sequence, and it present...
The quadruplex forming G-rich sequences are unevenly distributed throughout the human genome. Their ...
Telomere shortening is primarily involved in cell death and cellular aging. However, telomerase can ...
G-quadruplex (GQ) DNA is a non-canonical DNA structure thought to form throughout the human genome. ...
The remarkable selectivity of N-methyl mesopor-phyrin IX (NMM) for G-quadruplexes (GQs) is long know...
N-Methyl mesoporphyrin IX (NMM) is exceptionally selective for G-quadruplexes (GQ) relative to duple...
<i>N-</i>Methyl mesoporphyrin IX (NMM) is exceptionally selective for G-quadruplexes (GQ) relative t...
The G-quadruplex (GQ) is a well-studied non-canonical DNA structure formed by G-rich sequences found...
G-quadruplexes (GQs) are noncauonical secondary structures of DNA that can adopt a multitude of diff...
The G-quadruplex (GQ) is a well-studied non-canonical DNA structure formed by G-rich sequences found...
N-methyl mesoporphyrin IX (NMM) is a water-soluble, non-symmetric porphyrin with excellent optical p...
G-quadruplexes (GQs) are non-canonical DNA structures composed of stacks of stabilized guanine tetra...
Non-canonical DNA structures known as G-quadruplexes (GQs) and i-motifs can form from G-rich and C-r...
G-rich DNA sequences have the potential to fold into non-canonical G-Quadruplex (GQ) structures impl...
G-rich DNA sequences have the potential to fold into non-canonical G-Quadruplex (GQ) structures impl...
AbstractStructural complexity is an inherent feature of the human telomeric sequence, and it present...
The quadruplex forming G-rich sequences are unevenly distributed throughout the human genome. Their ...
Telomere shortening is primarily involved in cell death and cellular aging. However, telomerase can ...
G-quadruplex (GQ) DNA is a non-canonical DNA structure thought to form throughout the human genome. ...