Organometallic Ruthenium Complexes of Novel Thiosemicarbazones

We present the preliminary results of a study of two novel thiosemicarbazones (TSCs) and theirruthenium complexes. The TSCs were prepared by refluxing thiosemicarbazide with 9-anthraldehyde or benzanthrone in ethanol for 3 hours. The metal complex of each ligand (complex I =[(r|6 -C6H6 )Ru(9-ant-TSC )(C1)]C1 and complex II= [(r|6 -C6H6 )Ru(benz-TSC)(Cl)]Cl) was prepared by refluxing the appropriate TSC with [(r|6 -C6H6 )RuCl 2 ] r The compounds were characterized using infrared, ultraviolet-visible, and NMRspectroscopy. Two different methods, the disk diffusion test and luminometry, were used to test the compounds against a variety of different bacterial strains for antibacterial activity. The most optimistic results were obtained for the 9-ant-TSC ligand, especially in relation to activity against Gram (+) bacteria. The metal complexes showed no measurable activity and further biological testing of the metal complexes is currently being conducted