SiO 2-NaHSO 4 as an efficient reusable heterogeneous catalyst for the one-pot three-component synthesis of octahydro-quinazolin-2, 5-diones in water

An environmentally benign method for the synthesis of octahydro-quinazolin-2, 5-diones by the reaction of aromatic aldehydes, dimedone, and urea in the presence of SiO 2-NaHSO 4 is reported. SiO 2-NaHSO 4 acts as an efficient, mild, and recyclable heterogeneous catalyst to give excellent yields within a short reaction time in water at 60-80°C