Epimerization free synthesis of O-acyl isodipeptides employing COMU
- Samarasimhareddy, M.
- Hemantha, H.P.
- Ananda, K.
- Sureshbabu, V.V.
Publication date
January 2012
DOI Publisher
Bentham Science Publishers Ltd. ISSN
0929-8665 Citation count (estimate)
3Abstract
O-Acyl isodipeptides are prepared by coupling Boc-Ser/Thr-OBzl with Fmoc-Xaa-OH employing COMU, well known third generation peptide coupling agent. The reaction proceeds with high yield and the chemical homogeneity of the synthesized molecules were established via chiral HPLC analyses. The O-acyl isodipeptide units play crucial role in the success of 'click peptide' protocol employed for assembling 'difficult sequence' peptides. © 2012 Bentham Science Publishers
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