Synthesis of Hybrid Peptidomimetics and Neoglycoconjugates Employing Click Protocol: Dual utility of Poc-group for inserting carbamate-triazole units into peptide backbone

Synthesis of new types of peptidomimetics and glycosylated amino acids possessing 1,2,3-triazole and carbamate moieties is described. Poc-protected amino acid esters/1-amino sugars were subjected to Cu(I) catalyzed 2+3cycloaddition with desired azides under click protocol to obtain novel peptide and carbohydrate mimetics. The reaction is rapid, efficient and all the products are isolated in good yield and excellent purity. © 2010 Springer Science+Business Media, LLC