Abstract This chapter focuses on the catalytic and regulatory features of the photoreceptor phosphodiesterase 6 (PDE6) that make it suitable as the central effector of the visual transduction pathway. Photoreceptor PDE6 is one of the 11 PDE family members that comprise the class I cyclic nucleotide PDE superfamily. These enzymes regulate the cellular levels of cAMP and/or cGMP. Some PDE families are specific for one cyclic nucleotide, while others are dual substrate enzymes. All class I PDEs possess a conserved catalytic region of approximately 270 amino acids located toward the C-terminus of the primary sequence. Most PDE families contain a regulatory region located within their N-terminal region. The primary sequences of the catalytic sub...
As the central effector of visual transduction, the regulation of photoreceptor phosphodiesterase (P...
The photoreceptor phosphodiesterase (PDE6) regulates the intracellular levels of the second messenge...
Of the 11 families of mammalian cyclic nucleotide phosphodiesterases (PDEs), 5 contain regulatory do...
The photoreceptor phosphodiesterase (PDE6) is a member of large family of Class I phosphodiesterases...
Photoreceptor phosphodiesterase (PDE6) is the central effector enzyme in visual excitation pathway i...
Phosphodiesterase 6 (PDE6) is highly concentrated in the retina. It is most abundant in the internal...
AbstractcGMP-phosphodiesterases of the PDE6 family are expressed in retinal photoreceptor cells, whe...
Abstract Photoreceptor phosphodiesterase (PDE6) is the central effector enzyme in visual excitation ...
Abstract The photoreceptor phosphodiesterase (PDE6) is the central effector enzyme in the phototrans...
Rod and cone photoreceptors of the vertebrate retina utilize cGMP as the primary intracellular messe...
Phosphodiesterase 6 (PDE6) is a critical enzyme in the eyesight-signaling pathway. When activated, P...
Phosphodiesterase 6C (PDE6C) is the catalytic subunit of the cone-specific photoreceptor phosphodies...
Photoreceptor phosphodiesterase 6 (PDE6) is the central effector of the visual excitation pathway in...
PDE6H is an 83-amino-acid regulatory protein that binds to and inhibits the catalytic activity of th...
Abstract The cGMP phosphodiesterase (PDE6) involved in visual transduction in photoreceptor cells co...
As the central effector of visual transduction, the regulation of photoreceptor phosphodiesterase (P...
The photoreceptor phosphodiesterase (PDE6) regulates the intracellular levels of the second messenge...
Of the 11 families of mammalian cyclic nucleotide phosphodiesterases (PDEs), 5 contain regulatory do...
The photoreceptor phosphodiesterase (PDE6) is a member of large family of Class I phosphodiesterases...
Photoreceptor phosphodiesterase (PDE6) is the central effector enzyme in visual excitation pathway i...
Phosphodiesterase 6 (PDE6) is highly concentrated in the retina. It is most abundant in the internal...
AbstractcGMP-phosphodiesterases of the PDE6 family are expressed in retinal photoreceptor cells, whe...
Abstract Photoreceptor phosphodiesterase (PDE6) is the central effector enzyme in visual excitation ...
Abstract The photoreceptor phosphodiesterase (PDE6) is the central effector enzyme in the phototrans...
Rod and cone photoreceptors of the vertebrate retina utilize cGMP as the primary intracellular messe...
Phosphodiesterase 6 (PDE6) is a critical enzyme in the eyesight-signaling pathway. When activated, P...
Phosphodiesterase 6C (PDE6C) is the catalytic subunit of the cone-specific photoreceptor phosphodies...
Photoreceptor phosphodiesterase 6 (PDE6) is the central effector of the visual excitation pathway in...
PDE6H is an 83-amino-acid regulatory protein that binds to and inhibits the catalytic activity of th...
Abstract The cGMP phosphodiesterase (PDE6) involved in visual transduction in photoreceptor cells co...
As the central effector of visual transduction, the regulation of photoreceptor phosphodiesterase (P...
The photoreceptor phosphodiesterase (PDE6) regulates the intracellular levels of the second messenge...
Of the 11 families of mammalian cyclic nucleotide phosphodiesterases (PDEs), 5 contain regulatory do...