Feasibility of tailored treatment based on risk stratification in patients with early rheumatoid arthritis
- Markusse, I.M. (Iris M.)
- Vries-Bouwstra, J.K. (Jeska) de
- Han, K.H. (Hubert)
- Lubbe, P.A. (Peter) van der
- Schouffoer, A.A. (Anne A.)
- Kerstens, P.J.S.M.
- Lems, W.F. (Willem)
- Huizinga, T.W.J. (Tom)
- Allaart, C.F. (Cornelia)
Publication date
January 2014
DOI Publisher
Springer Science and Business Media LLCAbstract
Introduction: Personalized medicine is the holy grail of medicine. The EULAR recommendations for the management of rheumatoid arthritis (RA) support differential treatment between patients with baseline characteristics suggestive of a non-poor prognosis (non-PP) or poor prognosis (PP) (presence of autoantibodies, a high inflammatory activity and damage on radiographs). We aimed to determine which prognostic risk groups benefit more from initial monotherapy or initial combination therapy. Methods: 508 patients were randomized t
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