Characterization of stationary phases in gas chromatography using linear solvation energy relationships

Includes bibliographical references (pages [66]-68)Linear solvation energy relationship (LSER) was used for characterization three stationary phases with cyano- function group : sebaconitrile, benzyl cyanide and tetracyanoethylated pentaerythritol(TCEPE). We examined the partition/retention behaviors of a thirty solute set on the above stationary phases at 120 °C with gas chromatography. With applying multiple linear correlation regression on the retention results, the characteristic coefficients of these phases are determined. For high volatile phase, such as, benzyl cyanide, we also explored an alternative approach to determine the characteristic coefficients at high temperature based on the retention behaviors at lower temperature. As judged by the regression criteria R2 and the residuals analyses, the LSER correlation coefficients obtained are of statistical validity. They provide a very good prediction for the solvation ability for the solute on the given stationary phase. Our study represent an effort to extend the LSER data base in terms of functional group representation, which is eventually a more effective approach to characterize the stationary phases of chromatography.M.S. (Master of Science