Abstract Secreted signalling molecules are important for the regulation of developmental cell responses. In the developing kidney, signalling occurs between epithelial ureteric bud and metanephric mesenchyme and in between their derivatives. Wnt6 gene activity was localized to the ureteric bud and newly formed branches of the ureteric tree during early stages of kidney development. In a classic organ culture system, Wnt6 signalling induced the activation of marker genes for early nephrogenesis. The metanephric mesenchymes isolated from the Wnt4 deficient embryos were also induced, and the Wnt4 gene became activated in the presence of a Wnt6 signalling source. We propose that Wnt-6 is involved as a metanephric inducer and controls nephrogen...
The mammalian kidney, the metanephros, is formed by a reciprocally inductive interaction between two...
The permanent mammalian kidney (metanephros) develops as a result of complex reciprocal tissue inter...
Background: Wnt11 is a member of the Wnt family of secreted signals controlling the early steps in u...
Abstract Several Wnt proteins are expressed in the embry-onic kidney during various stages of develo...
AbstractA number of Wnt genes are expressed during, and are known to be essential for, early kidney ...
As in most organs, the emerging theme in kidney development is the importance of cross-talk between ...
AbstractGenetic interactions regulating intermediate stages of tubulogenesis in the developing kidne...
Abstract The kidney is a complex organ that is comprised of thousands of nephrons developing throug...
AbstractWnt4 and β-catenin are both required for nephrogenesis, but studies using TCF-reporter mice ...
Using stage-specific over-expression in transgenic Xenopus embryos, I show that both Wnt6 and β-cate...
AbstractThe kidney develops by cycles of ureteric bud branching and nephron formation. The cycles be...
AbstractIn the vertebrate embryo, development of the excretory system is characterized by the succes...
The metanephric (permanent) kidney of the mouse is an exceptionally well-studied example of organ de...
Kidney development involves complex morphogenetic interactions, some of which are not currently well...
Autosomal dominant polycystic kidney disease (PKD) is caused by mutations of the PKD1 or PKD2 genes...
The mammalian kidney, the metanephros, is formed by a reciprocally inductive interaction between two...
The permanent mammalian kidney (metanephros) develops as a result of complex reciprocal tissue inter...
Background: Wnt11 is a member of the Wnt family of secreted signals controlling the early steps in u...
Abstract Several Wnt proteins are expressed in the embry-onic kidney during various stages of develo...
AbstractA number of Wnt genes are expressed during, and are known to be essential for, early kidney ...
As in most organs, the emerging theme in kidney development is the importance of cross-talk between ...
AbstractGenetic interactions regulating intermediate stages of tubulogenesis in the developing kidne...
Abstract The kidney is a complex organ that is comprised of thousands of nephrons developing throug...
AbstractWnt4 and β-catenin are both required for nephrogenesis, but studies using TCF-reporter mice ...
Using stage-specific over-expression in transgenic Xenopus embryos, I show that both Wnt6 and β-cate...
AbstractThe kidney develops by cycles of ureteric bud branching and nephron formation. The cycles be...
AbstractIn the vertebrate embryo, development of the excretory system is characterized by the succes...
The metanephric (permanent) kidney of the mouse is an exceptionally well-studied example of organ de...
Kidney development involves complex morphogenetic interactions, some of which are not currently well...
Autosomal dominant polycystic kidney disease (PKD) is caused by mutations of the PKD1 or PKD2 genes...
The mammalian kidney, the metanephros, is formed by a reciprocally inductive interaction between two...
The permanent mammalian kidney (metanephros) develops as a result of complex reciprocal tissue inter...
Background: Wnt11 is a member of the Wnt family of secreted signals controlling the early steps in u...