Add to ORKGAbstract In tumourigenesis, genetic alterations accumulate in the genes responsible for cell growth, proliferation and DNA repair: proto-oncogenes, tumour suppressor and DNA repair genes. Inactivation of tumour suppressor gene function is commonly recognised as a deletion of one of the two alleles; LOH, loss of heterozygosity. In the present study, LOH of several chromosomal regions was studied in both breast and ovarian cancer. LOH for chromosome region 11q was examined in a large breast cancer consortium cohort (N = 988) and in a Finnish ovarian cancer cohort (N = 78), and the clinical significance of these alterations was evaluated. In breast cancer, LOH of the studied markers at 11q23.1, harbouring approximately 2 Mb of DNA, was seen ...
Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be inv...
Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be inv...
Breast cancer accounts for approximately 20% of all female malignancies with hereditary breast cance...
Ovarian carcinoma (OC) is the commonest gynaecological cause of death in the Western world. As a ste...
S_mnuary We examined DNA from 116 female and four male breast cancer patients for loss of heterozygo...
We examined DNA from 116 female and four male breast cancer patients for loss of heterozygosity (LOH...
Identification of the key genetic alterations leading to ovarian cancer is in its infancy. Polymeras...
Identification of the key genetic alterations leading to ovarian cancer is in its infancy. Polymeras...
Identification of the key genetic alterations leading to ovarian cancer is in its infancy. Polymeras...
Abstract As the defects in DNA repair and cell cycle control are known to promote tumorigenesis, a p...
Loss of constitutive heterozygosity at 11q23 has been detected in various human solid tumors. Here, ...
Deletions at chromosome 11q23 are frequent events in a variety of human neoplasms, including breast,...
Studies of loss of heterozygosity (LOH) in breast tumor DNA suggest that several tumor suppressor ge...
The molecular events that give rise to ovarian epithelial neoplasms are not well understood. In part...
Objectives. Ovarian cancer remains a major health problem for women. Although there is considerable ...
Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be inv...
Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be inv...
Breast cancer accounts for approximately 20% of all female malignancies with hereditary breast cance...
Ovarian carcinoma (OC) is the commonest gynaecological cause of death in the Western world. As a ste...
S_mnuary We examined DNA from 116 female and four male breast cancer patients for loss of heterozygo...
We examined DNA from 116 female and four male breast cancer patients for loss of heterozygosity (LOH...
Identification of the key genetic alterations leading to ovarian cancer is in its infancy. Polymeras...
Identification of the key genetic alterations leading to ovarian cancer is in its infancy. Polymeras...
Identification of the key genetic alterations leading to ovarian cancer is in its infancy. Polymeras...
Abstract As the defects in DNA repair and cell cycle control are known to promote tumorigenesis, a p...
Loss of constitutive heterozygosity at 11q23 has been detected in various human solid tumors. Here, ...
Deletions at chromosome 11q23 are frequent events in a variety of human neoplasms, including breast,...
Studies of loss of heterozygosity (LOH) in breast tumor DNA suggest that several tumor suppressor ge...
The molecular events that give rise to ovarian epithelial neoplasms are not well understood. In part...
Objectives. Ovarian cancer remains a major health problem for women. Although there is considerable ...
Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be inv...
Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be inv...
Breast cancer accounts for approximately 20% of all female malignancies with hereditary breast cance...