Hepatic steatosis in HIV-HCV coinfected patients receiving antiretroviral therapy is associated with HCV-related factors but not antiretrovirals.

Martinez, Valrie
TA, Thi,
Mokhtari, Zahra
Guiguet, Marguerite
Miailhes, Patrick
Valantin, Marc-Antoine
Charlotte, Frderic
Bertheau, Philippe
Molina, Jean-Michel
Katlama, Christine
Caumes, Eric

Open link

Publication date

April 2012

DOI

10.1186/1756-0500-5-180

Publisher

Springer Science and Business Media LLC

Abstract

International audienceABSTRACT: BACKGROUND: In HIV and hepatitis C virus (HCV) coinfected patients, the role of antiretroviral therapy (ART) on hepatic steatosis (HS) remains controversial. METHODS: HIV/HCV coinfected patients receiving ART and previously untreated for HCV who underwent a liver biopsy were included. Cumulative duration of exposure to each antiretroviral was recorded up to liver biopsy date. Logistic regression analyses evaluated factors associated with steatosis and its severity. RESULTS: 184 patients were included: median age 41 years, 84% male, 89% Caucasian, 61% with a past history of intravenous drug use. HCV genotypes were 1 (55%), 2 (6%), 3 (26%), and 4 (13%). Median HCV-RNA was 6.18 log10 IU/ml. HIV-RNA was undetecta...