Separation of enantiomers of drugs by capillary electrophoresis - V. Hydroxypropyl-alpha-cyclodextrin as chiral solvating agent

In an extended chiral drug screening program, enantioseparation of 86 racemic drugs was tested with hydroxypropyl-alpha-cyclodextrin as chiral solvating agent (CSA). A total of 34 drugs out of 86 could be resolved in this straightforward approach. The number of experiments performed under identical conditions allows a correlation of the separation factors alpha(m) with the interaction strengths R-m. As shown for a subset of 23 drugs, the concentration of the CSA is a crucial parameter for further optimization. (C) 1998 Elsevier Science B.V