A mild and efficient cyanosilylation of ketones using in situ generated N-oxides-Ti(iPrO)(4) complexes as catalysts
- Shen, YC
- Feng, XM
- Li, Y
- Zhang, GL
- Jiang, YZ
- Feng, XM, Sichuan Univ, Fac Chem, Sichuan Key LGreen Chem & Technol, Chengdu 610064, Peoples R China.
DOIAbstract
The addition of TMSCN to ketones catalyzed by complex of racemic N-(2'-pyridylmethyl)-2-diphenylhydroxymethylpyrrolidine N-oxide (rac-1) or N-benzyl-N,N-dihydroxyethylamine N-oxide and Ti(iPrO)(4) affords the racemic O-TMS cyanohydrins in good to excellent isolated yields (up to 97%) under mild reaction conditions
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