Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9
- Zhu, Liangliang
- Ge, Guangbo
- Liu, Yong
- He, Guiyuan
- Liang, Sicheng
- Fang, Zhongze
- Dong, Peipei
- Cao, Yunfeng
- Yang, Ling
- 杨凌
Publication date
October 2012
DOI ISSN
0049-8254 Citation count (estimate)
33Abstract
1. Human exposure to magnolol can reach a high dose in daily life. Our previous studies indicated that magnolol showed high affinities to several UDP-glucuronosyltransferases (UGTs) This study was designed to examine the in vitro inhibitory effects of magnolol on UGTs, and further to evaluate the possibility of the in vivo inhibition that might happen
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