Synthesis of 1,2,3-triazole moiety-containing NAD analogs and their potential as redox cofactors

Hou, Shuhua
Liu, Wujun
Ji, Debin
Wang, Qian
Zhao, Zongbao Kent
赵宗保

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Publication date

November 2011

DOI

10.1016/j.tetlet.2011.08.152

ISSN

0040-4039

Citation count (estimate)

Abstract

Synthesis of 1,2,3-triazole moiety-containing NAD analogs and their potential as redox cofactorsThirteen 1,2,3-triazole moiety-containing NAD analogs were synthesized and evaluated as redox cofactors. Noticeable enzymatic activities were observed when these analogs were employed as cofactors for malic enzyme or alcohol dehydrogenase. Our results indicated that the natural NAD-dependent oxidoreductases possessed flexible NAD binding pockets. (C) 2011 Elsevier Ltd. All rights reserved

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Synthesis of 1,2,3-triazole moiety-containing NAD analogs and their potential as redox cofactors

Abstract

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Synthesis of 1,2,3-triazole moiety-containing NAD analogs and their potential as redox cofactors

Abstract

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