Biochemical , Effects of hypolip in induced Hyperchlostrolemic Rats

The present study was carried out toinvestigate the biochemical effects of Hypolip, anew simvastatin drug, on serum total cholesterol,low density lipoprotein ( LDL-C) ,and to assess its effects on liver function and muscle haematological and histopathological finding. Twenty five Wister albino rats were divided into five groups. group (A) was fed basal diet only ( a control group) and the other four groups (B, C, D and E) were fed 1%cholesterol-containing diet for 2 weeks to induce hypercholesterolemia. After two weeks, groups (C, D and E) were orally administrated simvastatin at a dose rate of 10, 40, and 80 mg/kg Bwt, respectively for 4 weeks. Blood samples were taken avery two weeks to investigate serum total cholesterol, LDL-C and haematological parameters. liver function test and creatine kinase were also examined. Biopsy from liver and muscle wereimmediately taken after rats were slaughtered, and fixed in 10% neutral formalin, for histopathological investigations. There was a significant (P<0.05)increase in the serum Totalcholesterol and (LDL-C) concentrations in groups B, C, D and E compared to the control A after two weeks. The body weights significantly (P<0.05) increased in the induced hypercholesterolemic rat after 4 weeks. Two weeks after administration of hypolip, there was a significant (P