Optimal Designs for Discriminating Between some Extensions of the Michaelis-Menten Model

In this paper some results on the problem of computing optimal designs for discriminating between rival models are provided. Using T-optimality for two rival models a compound criterion is developed to discriminate between more than two models. Surprising results arise when T-optimal designs are compared with classical c-optimal designs for nonlinear models. In particular, some practical deviations of the Michaelis-Menten model are considered in order to measure and compare efficiencies of different designs.Optimal design, compound designs, pharmacokinetic models, T-optimality,