ALTERACI 3N DE LAS AMINOTRANSFERASAS S\uc9RICAS Y DEL COCIENTE AST/ALT EN EL ENVENENAMIENTO EXPERIMENTAL POR VENENO DE CROTALUS VEGRANDIS Y CROTALUS DURISSUS CUMANENSIS EN RATONES NMRI

El h\uedgado es susceptible a la toxicidad del veneno de cascabel, su funcionamiento puede ser monitoreado mediante las transaminasas. Se determinaron los niveles s\ue9ricos de transaminasas y su cociente, en el envenenamiento experimental con veneno de Crotalus vegrandis (CV) y de Crotalus durissus cumanensis (CDC). Sesenta ratones divididos en 3 grupos, 2 experimentales inoculados con pool de veneno de CV o CDC a una dosis de 0,75 mg/kg v\ueda intraperitoneal y ssf para el control. Se determinaron las enzimas a las 3, 6, 12 y 24 horas post-inyecci\uf3n. Los grupos inoculados con veneno de CDC mostraron aumento altamente significativo (P Palabras clave: Veneno de Crotalus, H\uedgado, Transaminasas. ABSTRACT The liver is susceptible to crotalus venom toxicity, its function may be monitored using transaminases. Transaminases level and their ratio were determinated in serum of experimental mice poisoning with Crotalus vegrandis venom (CV) and Crotalus durissus cumanensis (CDC). 60 mice divided into three groups, two experimental inoculated with venom pool CDC or CV were at a dose of 0.75 mg/kg intraperitoneally and control ssf. Enzymes were determined at 3, 6, 12 and 24 hours post-injection. The groups inoculated with venom CDC showed highly significant increase (P <0.01) in serum ALT levels at 12 and 24 hours compared to control, whereas with increasing venom CV higher and started at 6 hours. The progressive and significant increase of AST was from 6 hours to the CDC group venom, whereas CV were higher and with earlier onset. The CV group AST/ALT ratio was singnificantly increased from 3 hours to the group CV and highly significant (P <0.01) at 6, 12 and 24 hours, whereas the increased CDV AST / ALT ratio is highly significant to the 6 hours. The results suggest that the CV venom produces greater damage to liver tissue than the CDC. The index AST/ALT could be used as an indicator of the severity of liver damage and its evolution in Crotalus toxicity. Key words: Crotalus venom, liver, transaminases.