Radiation oncologists have observed variation in normal tissue responses between patients in many instances with no apparent explanation. The association of clinical tissue radiosensitivity with specific genetic repair defects (Wegner’s syndrome, Ataxia telangiectasia, Bloom’s syndrome, and Fanconi anemia) has been well established, but there are unexplained differences between patients in the general population with respect to the intensity and rapidity of appearance of normal tissue toxicity including radiation dermatitis, oral cavity mucositis, esophagitis, as well as differences in response of normal tissues to standard analgesic or other palliative measures. Strategies for the use of clinical radioprotectors have included modalities de...
PURPOSE: To evaluate the in vitro radioprotective effect of the mitochondria-targeted hemigramicidin...
Several clinically used drugs are mitotoxic causing mitochondrial DNA (mtDNA) variations, and thereb...
The clinical management of head and neck squamous cell carcinoma (HNSCC) commonly involves chemoradi...
Radiation oncologists have observed variation in normal tissue responses between patients in many in...
Fanconi anemia (FA) is an inherited disorder characterized by defective DNA repair and cellular sens...
Fanconi anemia (FA) is an inherited disorder characterizedby defective DNA repair and cellular sensi...
© 2017 Dr Jai SmithThe unavoidable irradiation of normal tissue during cancer radiotherapy can lead ...
International audiencePURPOSE: Human diseases associated with acute radiation responses are rare gen...
Radiation-induced DNA damage is a precursor to mutagen-esis and cytotoxicity. During radiotherapy, e...
Radiation-induced DNA damage is a precursor to mutagenesis and cytotoxicity. During radiotherapy, ex...
The clinical management of head and neck squamous cell carcinoma (HNSCC) commonly involves chemoradi...
Several clinically used drugs are mitotoxic causing mitochondrial DNA (mtDNA) variations, and thereb...
Oncogenes, activated copies of normal cellular genes, are involved in carcinogenesis and have been s...
The individual response to ionizing radiation (IR) raises a number of medical, scientific, and socie...
The oncogenic effect of ionizing radiation (IR) is clearly established and occurs in response to DNA...
PURPOSE: To evaluate the in vitro radioprotective effect of the mitochondria-targeted hemigramicidin...
Several clinically used drugs are mitotoxic causing mitochondrial DNA (mtDNA) variations, and thereb...
The clinical management of head and neck squamous cell carcinoma (HNSCC) commonly involves chemoradi...
Radiation oncologists have observed variation in normal tissue responses between patients in many in...
Fanconi anemia (FA) is an inherited disorder characterized by defective DNA repair and cellular sens...
Fanconi anemia (FA) is an inherited disorder characterizedby defective DNA repair and cellular sensi...
© 2017 Dr Jai SmithThe unavoidable irradiation of normal tissue during cancer radiotherapy can lead ...
International audiencePURPOSE: Human diseases associated with acute radiation responses are rare gen...
Radiation-induced DNA damage is a precursor to mutagen-esis and cytotoxicity. During radiotherapy, e...
Radiation-induced DNA damage is a precursor to mutagenesis and cytotoxicity. During radiotherapy, ex...
The clinical management of head and neck squamous cell carcinoma (HNSCC) commonly involves chemoradi...
Several clinically used drugs are mitotoxic causing mitochondrial DNA (mtDNA) variations, and thereb...
Oncogenes, activated copies of normal cellular genes, are involved in carcinogenesis and have been s...
The individual response to ionizing radiation (IR) raises a number of medical, scientific, and socie...
The oncogenic effect of ionizing radiation (IR) is clearly established and occurs in response to DNA...
PURPOSE: To evaluate the in vitro radioprotective effect of the mitochondria-targeted hemigramicidin...
Several clinically used drugs are mitotoxic causing mitochondrial DNA (mtDNA) variations, and thereb...
The clinical management of head and neck squamous cell carcinoma (HNSCC) commonly involves chemoradi...