Characterization of a Mycobacterium Smegmatis Mutant that is Simultaneously Resistant to D-Cycloserine and Vancomycin.
- Peteroy, M
- Severin, A
- Zhao, F
- Rosner, D
- Lopatin, U
- Scherman, H
- Belanger, A
- Harvey, B
- Hatfull, Graham F.
- Brennan, P J
- Connell, N D
Publication date
June 2000
DOI Publisher
American Society for MicrobiologyAbstract
A mutant of Mycobacterium smegmatis has been isolated that is simultaneously resistant to both D-cycloserine (D-CS) and vancomycin. Genetic complementation with a PBP4 homolog restores sensitivity to both drugs. Resistance to D-CS and vancomycin in this mutant is most likely due to a novel mechanism involving peptidoglycan assembly at the cell surface.\ud \u
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