Benzyl isothiocyanate (BITC), a constituent of edible cruciferous vegetables, inhibits growth of breast cancer cells but the mechanisms underlying growth inhibitory effect of BITC are not fully understood. Here, we demonstrate that BITC treatment causes FoxO1-mediated autophagic death in cultured human breast cancer cells. The BITC-treated breast cancer cells (MDA-MB-231, MCF-7, MDA-MB-468, BT-474, and BRI-JM04) and MDA-MB-231 xenografts from BITC-treated mice exhibited several features characteristic of autophagy, including appearance of double-membrane vacuoles (transmission electron microscopy) and acidic vesicular organelles (acridine orange staining), cleavage of microtubule-associated protein 1 light chain 3 (LC3), and/or suppression ...
Nasturtium (Tropaeolum majus L.) contains high concentrations of benzylglcosinolate. We found that a...
<div><p>Vitamin E succinate (VES), a potential cancer therapeutic agent, potently induces apoptosis ...
Vitamin E succinate (VES), a potential cancer therapeutic agent, potently induces apoptosis and inhi...
Benzyl isothiocyanate (BITC), a constituent of edible cruciferous vegetables, inhibits growth of bre...
Benzyl isothiocyanate (BITC), a constituent of edible cruciferous vegetables, inhibits growth of bre...
We recently reported that methyl 2-(-5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (M...
[[abstract]]Many evidences have shown that dietary intake of cruciferous vegetables could protect ag...
Benzyl isothiocyanate (BITC), a constituent of edible cruciferous vegetables, decreases viability of...
[[abstract]]Benzyl isothiocyanates (BITC), a member of the isothiocyanate (ITC) family, inhibits cel...
Although Beclin 1 and mTOR are considered to be the main molecules to modulate the autophagic proces...
Benzyl isothiocyanate (BITC), a constituent of edible cruciferous vegetables, decreases viability of...
[[abstract]]It is well known that the response of cancer cells to chemotherapeutic drugs involves th...
[[abstract]]Benzyl isothiocyanate (BITC), a component of dietary cruciferous vegetables, has antioxi...
Falcarindiol (FAD) is a natural polyyne have been found in many food and dietary plants. It has been...
Benzyl isothiocyanate (BITC) has been shown to inhibit invasion and induce apoptosis of various type...
Nasturtium (Tropaeolum majus L.) contains high concentrations of benzylglcosinolate. We found that a...
<div><p>Vitamin E succinate (VES), a potential cancer therapeutic agent, potently induces apoptosis ...
Vitamin E succinate (VES), a potential cancer therapeutic agent, potently induces apoptosis and inhi...
Benzyl isothiocyanate (BITC), a constituent of edible cruciferous vegetables, inhibits growth of bre...
Benzyl isothiocyanate (BITC), a constituent of edible cruciferous vegetables, inhibits growth of bre...
We recently reported that methyl 2-(-5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (M...
[[abstract]]Many evidences have shown that dietary intake of cruciferous vegetables could protect ag...
Benzyl isothiocyanate (BITC), a constituent of edible cruciferous vegetables, decreases viability of...
[[abstract]]Benzyl isothiocyanates (BITC), a member of the isothiocyanate (ITC) family, inhibits cel...
Although Beclin 1 and mTOR are considered to be the main molecules to modulate the autophagic proces...
Benzyl isothiocyanate (BITC), a constituent of edible cruciferous vegetables, decreases viability of...
[[abstract]]It is well known that the response of cancer cells to chemotherapeutic drugs involves th...
[[abstract]]Benzyl isothiocyanate (BITC), a component of dietary cruciferous vegetables, has antioxi...
Falcarindiol (FAD) is a natural polyyne have been found in many food and dietary plants. It has been...
Benzyl isothiocyanate (BITC) has been shown to inhibit invasion and induce apoptosis of various type...
Nasturtium (Tropaeolum majus L.) contains high concentrations of benzylglcosinolate. We found that a...
<div><p>Vitamin E succinate (VES), a potential cancer therapeutic agent, potently induces apoptosis ...
Vitamin E succinate (VES), a potential cancer therapeutic agent, potently induces apoptosis and inhi...