Palladin Mutation Causes Familial Pancreatic Cancer and Suggests a New Cancer Mechanism
- Pogue-Geile, Kay L.
- Chen, Ru
- Bronner, Mary P.
- Crnogorac-Jurcevic, Tatjana
- Moyes, Kara White
- Dowen, Sally
- Otey, Carol A.
- Crispin, David A.
- George, Ryan D.
- Whitcomb, David C.
- Brentnall, Teresa A.
Publication date
January 2006
DOI Publisher
Public Library of Science (PLoS)Abstract
Pancreatic cancer is a deadly disease. Discovery of the mutated genes that cause the inherited form(s) of the disease may shed light on the mechanism(s) of oncogenesis. Previously we isolated a susceptibility locus for familial pancreatic cancer to chromosome location 4q32-34. In this study, our goal was to discover the identity of the familial pancreatic cancer gene on 4q32 and determine the function of that gene
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