Pneumocystis (PC) pneumonia is a life-threatening opportunistic fungal infection observed in individuals with severe immunodeficiencies, such as AIDS. This dissertation evaluates functions of antibodies and conserved fungal cell wall carbohydrate antigens in host defense against PC. We demonstrate that a novel recombinant protein consisting of the extracellular domain of the beta-glucan receptor dectin-1 fused to the constant portion of murine IgG1, binds beta-glucan and recognizes Fc-γ receptors; and functionally, impairs growth of PC in the lungs of immunocompromised mice. As an antibody-like molecule targeting a conserved fungal cell wall carbohydrate enhanced host defense against PC, we questioned whether the host produces similar antib...
Streptococcus pneumoniae is a bacterial microorganism that frequently causes serious infection, part...
The incidence of fungal infections has dramatically increased in recent years, in large part due to ...
International audienceInvasive infections caused by spp. are associated with high mortality. Coloniz...
Pneumocystis (PC) pneumonia is a life-threatening opportunistic fungal infection observed in individ...
Natural IgM antibodies in diverse species recognize conserved carbohydrates in fungal cell walls and...
Pneumocystis carinii (PC) pneumonia is a leading opportunistic infection found among HIV-infected in...
The opportunistic pathogen Pneumocystis jirovecii is a significant cause of disease in HIV-infected ...
Anti-b-glucan antibodies elicited by a laminarin-conjugate vaccine confer cross-protection to mice c...
fungal pathogens such as Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans. To gai...
Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening pneumonia a...
Pneumocystis is an important opportunistic fungus that causes pneumonia in children and immunocompro...
Abstract: During fungal infection, a variety of receptors initiates immune responses, including TLR ...
Fungal pathogens can be recognized by the immune system via their beta-glucan, a potent proinflammat...
Fungal pathogens can be recognized by the immune system via their b-glucan, a potent proinflammatory...
<p>MSG and β-1,3-glucan are the main surface proteins of PC recognized by the host; however, novel T...
Streptococcus pneumoniae is a bacterial microorganism that frequently causes serious infection, part...
The incidence of fungal infections has dramatically increased in recent years, in large part due to ...
International audienceInvasive infections caused by spp. are associated with high mortality. Coloniz...
Pneumocystis (PC) pneumonia is a life-threatening opportunistic fungal infection observed in individ...
Natural IgM antibodies in diverse species recognize conserved carbohydrates in fungal cell walls and...
Pneumocystis carinii (PC) pneumonia is a leading opportunistic infection found among HIV-infected in...
The opportunistic pathogen Pneumocystis jirovecii is a significant cause of disease in HIV-infected ...
Anti-b-glucan antibodies elicited by a laminarin-conjugate vaccine confer cross-protection to mice c...
fungal pathogens such as Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans. To gai...
Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening pneumonia a...
Pneumocystis is an important opportunistic fungus that causes pneumonia in children and immunocompro...
Abstract: During fungal infection, a variety of receptors initiates immune responses, including TLR ...
Fungal pathogens can be recognized by the immune system via their beta-glucan, a potent proinflammat...
Fungal pathogens can be recognized by the immune system via their b-glucan, a potent proinflammatory...
<p>MSG and β-1,3-glucan are the main surface proteins of PC recognized by the host; however, novel T...
Streptococcus pneumoniae is a bacterial microorganism that frequently causes serious infection, part...
The incidence of fungal infections has dramatically increased in recent years, in large part due to ...
International audienceInvasive infections caused by spp. are associated with high mortality. Coloniz...