The nicotinic acetylcholine receptor (nAChR) mediates fast signal transduction in peripheral and central nervous systems. It is a pentameric ion channel that belongs to the Cys-loop receptor superfamily. nAChR is one of the plausible targets for general anesthetics. The current concern about nAChR is ambivalent structures of the transmembrane (TM) domain, missing information for the intracellular (IC) domain and elusive mechanisms of the action of general anesthetics. Therefore, this thesis focuses on the following two important aspects: first, the structure and dynamics of the nAChR TM and IC domains; and second, general anesthetic effects on various proteins. Part I. The secondary structure of human nAChR α7 TM domain and the monomeric te...
Ion channels play crucial roles in nervous system activities. The significance of ion channel functi...
International audienceWe present a three-dimensional model of the homopentameric alpha7 nicotinic ac...
<div><p>Nicotinic acetylcholine receptors (nAchRs) are ligand-gated ion channels that regulate chemi...
The nicotinic acetylcholine receptor (nAChR) mediates fast signal transduction in peripheral and cen...
AbstractThe molecular basis of anesthetic interaction with membrane proteins has been explored via d...
The nicotinic acetylcholine receptor (nAChR) is an important therapeutic target for a wide range of ...
AbstractThe nicotinic acetylcholine receptor (nAChR) is an important therapeutic target for a wide r...
Despite the widespread clinical use of anesthetics since the 19th century, a clear understanding of ...
The goal of the research was to investigate the secondary structure and orientation of the channel f...
AbstractThe α4β2 nicotinic acetylcholine receptor (nAChR) has significant roles in nervous system fu...
AbstractThe α7 nicotinic acetylcholine receptor (nAChR), assembled as homomeric pentameric ligand-ga...
Nicotinic acetylcholine receptors (nAChRs) are ligand- gated ion channels that mediate rapid neurotr...
AbstractThe recent cryoelectron microscopy structure of the Torpedo nicotinic acetylcholine receptor...
For over 160 years, general anesthetics have been given for the relief of pain and suffering. While ...
AbstractA three-dimensional model of the transmembrane domain of a neuronal-type nicotinic acetylcho...
Ion channels play crucial roles in nervous system activities. The significance of ion channel functi...
International audienceWe present a three-dimensional model of the homopentameric alpha7 nicotinic ac...
<div><p>Nicotinic acetylcholine receptors (nAchRs) are ligand-gated ion channels that regulate chemi...
The nicotinic acetylcholine receptor (nAChR) mediates fast signal transduction in peripheral and cen...
AbstractThe molecular basis of anesthetic interaction with membrane proteins has been explored via d...
The nicotinic acetylcholine receptor (nAChR) is an important therapeutic target for a wide range of ...
AbstractThe nicotinic acetylcholine receptor (nAChR) is an important therapeutic target for a wide r...
Despite the widespread clinical use of anesthetics since the 19th century, a clear understanding of ...
The goal of the research was to investigate the secondary structure and orientation of the channel f...
AbstractThe α4β2 nicotinic acetylcholine receptor (nAChR) has significant roles in nervous system fu...
AbstractThe α7 nicotinic acetylcholine receptor (nAChR), assembled as homomeric pentameric ligand-ga...
Nicotinic acetylcholine receptors (nAChRs) are ligand- gated ion channels that mediate rapid neurotr...
AbstractThe recent cryoelectron microscopy structure of the Torpedo nicotinic acetylcholine receptor...
For over 160 years, general anesthetics have been given for the relief of pain and suffering. While ...
AbstractA three-dimensional model of the transmembrane domain of a neuronal-type nicotinic acetylcho...
Ion channels play crucial roles in nervous system activities. The significance of ion channel functi...
International audienceWe present a three-dimensional model of the homopentameric alpha7 nicotinic ac...
<div><p>Nicotinic acetylcholine receptors (nAchRs) are ligand-gated ion channels that regulate chemi...