Numerous reports correlate nitric oxide (•NO) production with stalled S-phase progression, but the molecular mechanism(s) of cell cycle arrest remains elusive. Paradoxically numerous human tumors are exposed to vast quantities of nitric oxide and its reactive byproducts in situ, yet they continue to grow and proliferate. The dual-specificity phosphatase Cdc25A promotes cell cycle progression by dephosphorylating and activating cyclin-dependent kinases. Deregulation of Cdc25A is characteristic of human tumors, accelerates the cell cycle, and confers resistance to apoptosis, highlighting the importance of stringent Cdc25A control. Biochemical and structural analyses of Cdc25A indicate the potential for inhibition by S-nitrosation of the catal...
The cell division cycle 25 (Cdc25) family of proteins are highly conserved dual specificity phosphat...
International audienceProgression in cell cycle is controlled by CDKs (cyclin dependent kinases) and...
CDC25 phosphatases play a key role in cell cycle transitions and are important targets for cancer th...
Numerous reports correlate nitric oxide (•NO) production with stalled S-phase progression, but the m...
Deregulation of normal cell cycle control is essential for malignant transformation. The Cdc25A dual...
AbstractThe Cdc25 phosphatases function as key regulators of the cell cycle during normal eukaryotic...
International audienceIn view of the common regulatory mechanism that induces transcription of the m...
The Cdc25 phosphatases are highly conserved from yeast through humans and play pivotal roles in regu...
The cell division cycle 25 (CDC25) phosphatases regulate key transitions between cell-cycle phases d...
Hypoxia represents an important element of the solid tumor microenvironment and contributes to tumor...
Loss of normal cell cycle control leading to unregulated proliferation is a hallmark of cancer. In a...
In this study, we assessed S-nitrosylation-based regulation of Janus-activated kinase 2/signal trans...
Cell division cycle 25 (Cdc25) phosphatases play a pivotal role in the regulation of cell cycle. Bec...
The Cdc25A protein phosphatase drives cell cycle transitions by activating cyclindependent protein k...
International audienceMounting evidence suggests that the position in the cell cycle of cells expose...
The cell division cycle 25 (Cdc25) family of proteins are highly conserved dual specificity phosphat...
International audienceProgression in cell cycle is controlled by CDKs (cyclin dependent kinases) and...
CDC25 phosphatases play a key role in cell cycle transitions and are important targets for cancer th...
Numerous reports correlate nitric oxide (•NO) production with stalled S-phase progression, but the m...
Deregulation of normal cell cycle control is essential for malignant transformation. The Cdc25A dual...
AbstractThe Cdc25 phosphatases function as key regulators of the cell cycle during normal eukaryotic...
International audienceIn view of the common regulatory mechanism that induces transcription of the m...
The Cdc25 phosphatases are highly conserved from yeast through humans and play pivotal roles in regu...
The cell division cycle 25 (CDC25) phosphatases regulate key transitions between cell-cycle phases d...
Hypoxia represents an important element of the solid tumor microenvironment and contributes to tumor...
Loss of normal cell cycle control leading to unregulated proliferation is a hallmark of cancer. In a...
In this study, we assessed S-nitrosylation-based regulation of Janus-activated kinase 2/signal trans...
Cell division cycle 25 (Cdc25) phosphatases play a pivotal role in the regulation of cell cycle. Bec...
The Cdc25A protein phosphatase drives cell cycle transitions by activating cyclindependent protein k...
International audienceMounting evidence suggests that the position in the cell cycle of cells expose...
The cell division cycle 25 (Cdc25) family of proteins are highly conserved dual specificity phosphat...
International audienceProgression in cell cycle is controlled by CDKs (cyclin dependent kinases) and...
CDC25 phosphatases play a key role in cell cycle transitions and are important targets for cancer th...