FORMULATION OF POPULATION PHARMACOKINETIC MODELS OF ANTI-CANCER AGENTS

The primary objective of the study is to assemble population pharmacokinetic models from the cancer pharmacokinetics literature for different types of anti-cancer drugs and to formulate them in ways suitable for input into cancer simulation programs. To fulfill the objectives, a step-based approach is adopted: 1)To catalogue the types of pharmacokinetic models through general review articles and books 2)To develop a search strategy for defining a body of research literature related to cancer pharmacokinetics in clinical trials for a limited set of drugs (Taxol, Platinum compounds. Fluoropyrimidine and Topoisomerase inhibitors) 3)To collect pharmacokinetic articles according to defined search criteria4)To gather information from the collected PK articles 5)To synthesize the information separately for each drug, using a questionnaire instrument and present them in template form for each class of antineoplastic agent.6)To formulate population pharmacokinetic models for each anti-cancer drug, from the constituent submodels for components of the overall model. This work will promote public health, specifically in support of the development of anti-cancer drug regimens for cancer patients, byproviding standardized information about pharmacokinetics for input into simulations