Melanoma is rapidly increasing in incidence throughout the world. Early stages are curable with surgical approaches with excellent prognosis. However, a substantial proportion of patients progress to metastatic disease with survival rates of less than 5% making melanoma the culprit for over 65% of all skin-cancer related deaths. Novel agents targeting the immune system and the signaling pathways of melanoma are generating new promise, but chemotherapy remains an important therapeutic alternative, despite low response rates. The resistance of melanoma to chemotherapy is in part due to DNA repair mechanisms that allow cells to survive alkylation damage. Several novel agents targeting the abrogation of DNA repair pathways alone and in combinat...
International audienceMalignant melanoma is the most deadly form of skin cancer. It originates from ...
Abstract: The treatment of melanoma has been revolutionized by new therapies targeting MAPK signalin...
Melanoma is the deadliest form of skin cancer with rising incidence and mortality rates. Although ea...
Melanoma is rapidly increasing in incidence throughout the world. Early stages are curable with surg...
Decitabine, an epigenetic modifier that reactivates genes otherwise suppressed by DNA promoter methy...
Decitabine, an epigenetic modifier that reactivates genes otherwise suppressed by DNA promoter methy...
Cutaneous melanoma is a lethal disease, even when diagnosed in advanced stages. Although recent prog...
Melanoma is an aggressive skin cancer reliant on early detection for high likelihood of successful t...
Treatment of resistant metastatic melanoma using sequential epigenetic therapy (decitabine and panob...
Melanoma is the deadliest form of skin cancer. The disease is driven by molecular alterations in onc...
Malignant melanoma is a complex disease that arises and evolves due to a myriad of genetic and epige...
Apoptosis genes, such as TP53 and p16/CDKN2A, that mediate responses to cytotoxic chemotherapy, are ...
Epigenetic alterations have emerged as essential contributors in the pathogenesis of various human d...
Cutaneous melanoma is a very aggressive neoplasia of melanocytic origin with constantly growing inci...
PURPOSE: Temozolomide, a DNA methylating agent used to treat melanoma, induces DNA damage, which is ...
International audienceMalignant melanoma is the most deadly form of skin cancer. It originates from ...
Abstract: The treatment of melanoma has been revolutionized by new therapies targeting MAPK signalin...
Melanoma is the deadliest form of skin cancer with rising incidence and mortality rates. Although ea...
Melanoma is rapidly increasing in incidence throughout the world. Early stages are curable with surg...
Decitabine, an epigenetic modifier that reactivates genes otherwise suppressed by DNA promoter methy...
Decitabine, an epigenetic modifier that reactivates genes otherwise suppressed by DNA promoter methy...
Cutaneous melanoma is a lethal disease, even when diagnosed in advanced stages. Although recent prog...
Melanoma is an aggressive skin cancer reliant on early detection for high likelihood of successful t...
Treatment of resistant metastatic melanoma using sequential epigenetic therapy (decitabine and panob...
Melanoma is the deadliest form of skin cancer. The disease is driven by molecular alterations in onc...
Malignant melanoma is a complex disease that arises and evolves due to a myriad of genetic and epige...
Apoptosis genes, such as TP53 and p16/CDKN2A, that mediate responses to cytotoxic chemotherapy, are ...
Epigenetic alterations have emerged as essential contributors in the pathogenesis of various human d...
Cutaneous melanoma is a very aggressive neoplasia of melanocytic origin with constantly growing inci...
PURPOSE: Temozolomide, a DNA methylating agent used to treat melanoma, induces DNA damage, which is ...
International audienceMalignant melanoma is the most deadly form of skin cancer. It originates from ...
Abstract: The treatment of melanoma has been revolutionized by new therapies targeting MAPK signalin...
Melanoma is the deadliest form of skin cancer with rising incidence and mortality rates. Although ea...