An Ornstein-Uhlenbeck process is the most basic mean-reversion model and has been used in various fields such as finance and biology. In some instances, reflecting boundary conditions are needed to restrict the state space of this process. We study an Ornstein-Uhlenbeck diffusion process with a reflecting boundary and its application to finance and neuroscience. In the financial application, the Vasicek model which is an Ornstein-Uhlenbeck process has been used to capture the stochastic movement of the short term interest rate in the market. The shortcoming of applying this model is that it allows a negative interest rate theoretically. Thus we use a reflected Ornstein-Uhlenbeck process as an interest rate model to get around this problem. ...